P690Role of sodium-hydrogen exchange in vascular failure in hereditary cardiomyopathy.
Bibliographic record
Abstract
Cardiomyopathy in general is defined as a disease of the heart muscle. The purpose of this study is to test the hypothesis that sodium-hydrogen exchanger (NHE1) abnormality is a common cause of cardiac and vascular failures in hereditary cardiomyopathy of the hamster. We verified whether heart failure is accompanied by vascular abnormalities in NHE1. In order to conduct this study we used complementary techniques such as measurement of mean arterial pressure, cardiac and vascular cells intracellular Ca2+, Na+ and NHE1 levels as well as real 3D confocal microscopy and Western blot. Our results show an increase in intracellular Ca2+ and Na+ that is associated with an increase in NHE1 levels and activities in both cardiac and vascular myocytes. In addition, these abnormalities were accompanied by necrosis and hypertrophy of cardiomyocytes but not of vascular myocytes. Furthermore, in addition to these cardiac and vascular defects, a decrease in mean arterial pressure was observed during the development of hereditary cardiomyopathy of the hamster. No changes in aortic thickness and the density of elastin were observed. In conclusion, our results suggest that hereditary cardiomyopathy is not only a cardiac disease but is also a vascular disease where NHE1 could be a common cause and that treatment with a NHE1 blocker would prevent not only the development of cardiac failure but also vascular failure.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".