Experimental immunology<br>Modulation of murine T and B lymphocyte subsets by polysaccharide fraction B isolated from <i>Caltha palustris L.</i>
Bibliographic record
Abstract
Various natural plant extracts have been shown to have the immunomodulatory activity. Caltha palustris L. (Ranunculaceae) is a plant that is widely known and distributed in Europe, Asia and North America. The extracts from Caltha palustris have been used in traditional Canadian and Asian medicine to treat arthritis rheumatism, gonorrhea and a variety of skin diseases. The effects of polysaccharide fraction B from Caltha palustris L. extract (0.1, 1 and 10 mg/kg) on the total number of lymphocytes in the thymus, spleen and mesenteric lymph nodes and the percentage and absolute number of T cells (CD4<sup>–</sup>CD8<sup>–</sup>, CD4<sup>+</sup>CD8<sup>+</sup>, CD4<sup>+</sup>, CD8<sup>+</sup>) in the thymus and T cells (CD3+, CD4<sup>+</sup>, CD8<sup>+</sup>) and B (CD19<sup>+</sup>) lymphocytes in the spleen and mesenteric lymph nodes in mice were studied. The investigated substance was administered intraperitoneally once or five times to mice. The measurements were determined twice: 24 and 72 h after the last administration of fraction B. It was found that five times administration of fraction B (0.1 mg/kg) from Caltha palustris extract significantly decreased the absolute count of CD8<sup>+</sup> thymic cells on both days. The increase in the CD4<sup>+</sup> lymphocyte population (thymus, spleen) after single administration of fraction B from Caltha palustris extract was noticed, however a decrease in this population was observed after the multiple administration in mesenteric lymph nodes. Whereas CD19<sup>+</sup> B lymphocyte population of spleen has been stimulated after five times administration of the tested agent. Results of the study demonstrated that fraction B from Caltha palustris extract can change the percentage and absolute number of T and B lymphocytes in lymphatic organs. The effect of the examined substance depends on the number of consecutive doses applied.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".