Identification of novel fragment-based hits for<i>P. berghei</i>orotidine 5′-monophosphate decarboxylase
Bibliographic record
Abstract
For a quarter of a century the isolation of polymorph from III of paracetamol has been a problem due to its instability. In 1997 P. Di Martino et al [1] published the first route to prepare form III of paracetamol but they were not able to observe an x-ray diffractogram from form III. Recently J.B. Burley et al [2] isolated the polymorphic form III, but they could not draw conclusions from the powder diffractogram due to the large non-crystalline fraction. In this paper we present x-ray powder diffraction data from paracetamol form III as well as data from forms II and I. Also data collected at non-ambient temperatures will be discussed. Lattice parameters and a structure for form III will be proposed on the basis of the collected x-ray powder diffraction data.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".