Decrease in Bilateral Corneal Deposits After Bortezomib/ Dexamethasone Chemotherapy in Monoclonal Gammopathy: Case Report
Bibliographic record
Abstract
Purpose: To evaluate changes of bilateral crystalline corneal deposits via biomicroscopic photography and in vivo confocal microscopy (IVCM) after systemic chemotherapy in a patient with monoclonal gammopathy. Methods: Ophthalmological examination, slit-lamp biomicroscopic photography and IVCM of each corneal quadrant were performed before and after 4 cycles of combined bortezomib and dexamethasone chemotherapy. Results: IVCM revealed mainly subepithelial crystalline deposits not affecting keratocytes or antigen presenting cells. After therapy, corneal opacity in slit-lamp biomicroscopic photography and crystalline deposits decreased visibly. Visual acuity remained stable. Subjective symptoms (haziness, photophobia) improved. Conclusions: This patient suffered from initially unknown monoclonal gammopathy manifesting in bilateral corneal deposits. Crystalline corneal deposits may be associated with systemic disorders such as monoclonal gammopathy. Correct diagnosis is crucial as systemic treatment may improve not only ophthalmological symptoms. Penetrating keratoplasty alone may lead to relapse.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".