Abstract 4645: Decreased CD4+ naive and effector memory T cell counts, and CD8+ naive T cell counts, are associated with trichloroethylene exposure
Bibliographic record
Abstract
Abstract Trichloroethylene (TCE) is a volatile chlorinated organic compound that is commonly used in the workplace as a degreaser for metal parts and general-purpose solvent for lipophilic compounds. Although TCE is considered an animal carcinogen, its carcinogenic potential in humans is uncertain. Occupational exposure to TCE has been associated with increased risk of kidney cancer and non-Hodgkin lymphoma in some studies, but findings are not fully consistent. We have carried out a cross-sectional study of 80 workers exposed to TCE and 96 unexposed controls matched on age and sex in Guangdong, China to study TCE's early biologic effects. We previously reported that the total lymphocyte count (but not the granulocyte count) and each of the major lymphocyte subsets (i.e., CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and B cells) were decreased in TCE-exposed workers compared to controls. These findings suggested a selective effect of TCE exposure on lymphoid progenitors and/or lymphocyte survival. To further study which subsets of lymphocytes are affected specifically, we investigated the effect of TCE exposure on the numbers of CD4+ naïve and memory T cells, CD8+ naïve and memory T cells, and regulatory T cells by FACS analysis. Linear regression using the natural logarithm (ln) of each subset was used to test for differences between exposed workers and controls adjusting for potential confounders such as age, sex, smoking status, alcohol consumption, recent infections, and body mass index. We observed that CD4+ and CD8+ naïve T cell counts were about 8% (p = 0.056) and 17% (p = 0.0002) lower, respectively, among exposed workers. Strikingly, CD4+ effector memory T cell counts were decreased by about 20% among TCE exposed workers compared to controls (p = 0.001) whereas the CD4+ central memory T cell population was not significantly changed. Intriguingly, the numbers of CD4+ central memory T cells, and CD8+ memory T cells including central and effector memory population, as well as regulatory T cells were not significantly different between the controls and exposed workers. Thus, TCE selectively targets CD4+ naïve and CD4+ effector memory T cells, and CD8+ naïve T cells. These findings provide further insights into the biologic response of human immune cells upon exposure to TCE, which may include immunosuppression through reduced capacity to respond to antigens. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4645. doi:10.1158/1538-7445.AM2011-4645
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".