ε-Caprolactone-Based Macromonomers Suitable for Biodegradable Nanoparticles Synthesis through Free Radical Polymerization
Bibliographic record
Abstract
New ε-caprolactone (CL)-based materials were synthesized. Bulk ring-opening polymerization of ε-caprolactone with 2-hydroxyethyl methacrylate (HEMA) as cocatalyst was carried out to produce various macromonomers composed of HEMA functionalized with 1–10 CL units. All of the HEMA-CL macromonomers have been characterized by size exclusion chromatography (SEC) and 1 H NMR. For SEC analysis universal calibration was applied, and Mark–Houwink parameters for poly(HEMA- g -CL 3 ) were obtained. Macromonomers with different CL chain length were polymerized through free radical polymerization, in both batch and semibatch emulsion polymerization to produce CL-based nanoparticles (NPs) with narrow particle size distribution. Various reactions parameters were investigated, namely the type of the emulsifier, the feeding conditions, and the macromonomer chain length. Finally, a simple and qualitative degradation study of selected samples was carried out in order to verify the degradability of these CL-based NPs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".