ε-Caprolactone-Based Macromonomers Suitable for Biodegradable Nanoparticles Synthesis through Free Radical Polymerization
Bibliographic record
Abstract
New ε-caprolactone (CL)-based materials were synthesized. Bulk ring-opening polymerization of ε-caprolactone with 2-hydroxyethyl methacrylate (HEMA) as cocatalyst was carried out to produce various macromonomers composed of HEMA functionalized with 1–10 CL units. All of the HEMA-CL macromonomers have been characterized by size exclusion chromatography (SEC) and 1 H NMR. For SEC analysis universal calibration was applied, and Mark–Houwink parameters for poly(HEMA- g -CL 3 ) were obtained. Macromonomers with different CL chain length were polymerized through free radical polymerization, in both batch and semibatch emulsion polymerization to produce CL-based nanoparticles (NPs) with narrow particle size distribution. Various reactions parameters were investigated, namely the type of the emulsifier, the feeding conditions, and the macromonomer chain length. Finally, a simple and qualitative degradation study of selected samples was carried out in order to verify the degradability of these CL-based NPs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".