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Record W2323179508 · doi:10.2174/1573396311309030005

Thrombotic Thrombocytopenic Purpura, from the Perspectives of a Pediatrician

2013· article· en· W2323179508 on OpenAlex
Howard H.W. Chan, Anthony K.C. Chan, Iakovina Alexopoulou, Keith K. Lau

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueCurrent Pediatric Reviews · 2013
Typearticle
Languageen
FieldMedicine
TopicIron Metabolism and Disorders
Canadian institutionsThrombosis and Atherosclerosis Research Institute
Fundersnot available
KeywordsThrombotic thrombocytopenic purpuraMedicineVon Willebrand factorPurpura (gastropod)DiseasePediatricsHemolytic anemiaImmunologyIntensive care medicinePlateletInternal medicine

Abstract

fetched live from OpenAlex

Thrombotic thrombocytopenic purpura (TTP) is a rare pediatric disease, yet has grave outcome if not managed properly. It shares many common clinical features with hemolytic uremic syndrome (HUS). While it is still disputable whether TTP and HUS are clinically related disorders, recent studies indicate that severe deficiency of a von Willebrand factor (vWF) cleaving protease is one of the primary causes of TTP. In this discussion, we will focus on TTP in reference to the deficiency of this protease, with the objective of increasing awareness among pediatric healthcare professionals of this less commonly recognized disease. Keywords: Thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, TTP, HUS.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.433
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.316
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it