601 Does Bronchopulmonary Dysplasia Relate to Redox Status in Infants Less than 29 Weeks of Gestational Age?
Bibliographic record
Abstract
Background Glutathione is the key molecule in detoxification of peroxides leading to an oxidized glutathione redox status (GRS). We hypothesizes that GRS plays an important role in the etiology of bronchopulmonary dysplasia (BPD). Objective To test the relation between GRS at 6–7 days of life as well as at 36 weeks of corrected age and BPD. To identifty perinatal factors affecting GRS. Design/methods Whole blood GRS was measured at 6–7 days of life and at 36 weeks of corrected age (CA) in 51 infants less than 29 weeks of gestational age (GA). Perinatal clinical data that may affect the GRS were colleted. The GRS was calcualted using concentration of GSH and GSSG according to the Nernst equation (Schafer & Buettner, 2001). Results Infants in our cohort had gestational age of 26±1 weeks with birth weight of 847±166 gm. Significant relation between GRS and BPD was confirmed with less risk of BPD in infants with most reduced GRS (day 6–7) and higher risk of BPD for infants with most oxidized GRS at 36 weeks CA. GA and BW were signifcantly related to GRS. Conclusions There is a significant relation between GRS 6–7 days of life as well as at 36 weeks CA and BPD outcome in infants less than 29 weeks of GA. The significant impact of both GA and BW on GRS at 6–7 days of life is explained by the glutathione level that is correlated with gestational age.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".