UC in a reference center in Salvador-Bahia/brazil: Epidemiological and clinical description
Bibliographic record
Abstract
Ulcerative Colitis (UC) is characterized by continuous inflammation of the lining of the rectum and colon and althought its pathogenesis is not established, it occurs from the result of an association between genetic and environmental factors. The incidence is higher in developed countries, but it has seen a growth in developing countries. In Brazil, there are few epidemiological studies on UC. To characterize patients with UC in a reference center in the city of Salvador-BA/Brazil. We designed a cross-sectional study in a referral center for adult patients diagnosed with IBD. Interviews with patients and chart review were conducted. Statistical analysis was performed using SPSS 17.0 (SPSS, Chicago, IL). Quantitative variables were expressed as median and variations or as mean ± SD when normally distributed. Qualitative variables were expressed as frequency. We included 200 patients, 123 (61.5%) with UC, 70 (35%) with CD and 7 (3.5%) with IC. We analyzed 123 patients with UC, which 76 (61.8%) were female. The average age was 44.20 years ± 14.22. The average time between symptom onset and diagnosis was 21.9 months. The average age at diagnosis was 37.35 years ± 12.59. In the self-declaration, 54 (43.9%) patients said they were mixed-race, 42 (34.1%) patients declared themselves as black and 19 (15.4%) patients reported they were white. Of the patients, 34.2% were smokers or had a history of smoking. Most of them (90.2%) had no family history of IBD. Regarding the location of UC according to the Montreal classification, 53 (43.1%) patients presented extensive colitis, 52 (42.3%) patients presented leftsided colitis and only 17 (13.8%) patients proctitis. Only 33 (26.8%) patients required hospitalization last year due to disease activity. Of these, two (1.6%) patients required total colectomy. As for medication, 106 (86.2%) patients were in 5-ASA therapy, which 57 (46.34%) were prescribed sulfasalazine, 40 (32.52%) oral mesalazine and 37 (30.8%) mesalazine suppository, including association between these drugs. Only 28 (22.8%) patients were taking azathioprine, 11 (8.9%) patients were taking steroids, and two (1.6%) patients were taking Anti-TNF therapy. There was a higher frequency of UC compared to CD, as reported in developing countries. Most patients were female and family history of IBD was infrequent, strengthening the importance of possible environmental factors as the etiology of the disease. The higher frequency of extensive colitis can be explained by the study had been performed in a referral center. Most patients were using 5-ASA, and a few patients were taking steroids or had been submitted to a colectomy which implies that the majority presented a good response to the maintenance therapy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".