The Phosphatidylinositol Synthase-Catalyzed Formation of Phosphatidylinositol Does Not Exhibit Acyl Chain Specificity
Bibliographic record
Abstract
Phosphatidylinositol (PI) and its phosphorylated forms are required for many critical cellular processes. PI is highly enriched at its sn-1 and sn-2 positions, the major species being 1-stearoyl-2-arachidonoyl PI (18:0/20:4 PI). This enrichment is achieved in part through enzymatic acyl chain specificity in PI synthesis. Here we characterize the acyl chain specificity of phosphatidylinositol synthase (PIS), which is involved in the terminal step of PI synthesis. Unlike several other enzymes involved in PI synthesis, PIS appears to exhibit no acyl chain specificity toward its substrates. Thus, enrichment of newly formed PI occurs prior to the terminal synthesis step.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".