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Record W2325849465 · doi:10.1128/microbe.8.482.1

Bacteria, Phages Share Needle-Like Virulence Proteins

2013· article· en· W2325849465 on OpenAlex
Marcia Stone

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueMicrobe Magazine · 2013
Typearticle
Languageen
FieldEnvironmental Science
TopicBacteriophages and microbial interactions
Canadian institutionsWorld Federation of Science Journalists
Fundersnot available
KeywordsBacteriaVirulenceBacteriophageMicrobiologySecretionBiologyType VI secretion systemHost (biology)GeneticsEscherichia coliGeneBiochemistry

Abstract

fetched live from OpenAlex

PAAR (proline-alanine-alanine-arginine) repeat proteins sharpen the ends of phage-like bacterial spikes known as type VI secretion systems (T6SS) —serving as “needles” for these complex organelles through which gram-negative bacteria inject toxins into host cells during infection, according to Petr G. Leiman at Ecole Polytechnique Federale de Lausanne in Switzerland and colleagues there as well as in the United States and Russia. Remarkably, phages encode and deploy nearly identical proteins to punch through the membranes of their bacterial host cells. Details appeared August 15, 2013 in Nature (500:350–353).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.769
Threshold uncertainty score0.952

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.1030.049

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.205
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it