Inhibition of the Calcineurin Pathway by Two Tannins, Chebulagic Acid and Chebulanin, Isolated from Harrisonia abyssinica Oliv.
Why this work is in the frame
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Bibliographic record
Abstract
In the past 20 years, the incidences of fungal infections, particularly opportunistic fungal infections, have significantly increased owing to the introduction of organ transplantation and cancer chemotherapy, and prevalence of AIDS [15,18].Less pathogenic species of Candida such as Candida dubliniensis and Saccharomyces cerevisiae, previously considered as clinically insignificant, are emerging as opportunistic pathogens affecting a variety of different body sites [5,8,10].An outbreak of meningitis due to the zoonotic fungus Cryptococcus neoformans on the east coast of Vancouver Island in Canada attracted public attention in the year 2000 because this strain causes life-threatening meningocephalitis in immunocompromised and immunocompetent individuals [9,12].However, most available antifungal compounds exhibit high toxicity and various harmful effects on human cells; moreover, pathogenic fungi are resistant to these antifungal compounds.Therefore, demand for the development of novel antifungal agents that have few side effects and a broad-spectrum activity against various fungi is greater than ever before.C. neoformans, a group of ubiquitous human and animal pathogen, is widely distributed in the environment and commonly isolated from avian excreta, soil, and trees.Disease is thought to progress upon inhalation of its basidiospores into the lungs, and then spreads from the lungs to the central nervous system to cause meningoencephalitis [17].Harrisonia abyssinica Oliv.(Simaroubaceae) is a small tree or shrub widely used in African folk remedies for the treatment of gonorrhea, dysentery, skin diseases, fever, bubonic plague, hemorrhoids, snakebite, and tuberculosis [1,16].The extracts of the bark and root of H. abyssinica have been found to exhibit in vitro antimicrobial, cytotoxic, insect antifeedant, antiviral, and molluscicidal activities [1,16], and stimulatory effects on Striga hermonthica seeds [2].
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it