New applications of<i>q</i>-dependent XRS across the periodic table
Bibliographic record
Abstract
The Cardin group has recently been successful [1] in determining the modes of binding to the DNA Holliday junction of a bisintercalator. The acridine chromophores of the bisintercalator replaced two adenine bases at the junction, see Figure . The mode of binding of these so-called bisintercalators is not intercalative, but displacement of the adenosines at position 6 of the crossover strands, and their replacement with acridine groups in the AT basepair. The 4-carboxamide sidechains thread through to the minor groove side of the junction but make no specific hydrogen bond. The acridine chromophore also makes no specific interaction with the unpaired thymine. Rather, the binding is stabilised by stacking interactions, g o o d s t e r i c f i t a n d c h a r g e n e u t r a l i s a t i o n . The Cardin group characterised the c r o s s l i n k i n g o f duplex DNA by the same compound [2]. T h i s t a l k w i l l i n c l u d e r e c e n t unpublished results demonstrating that recognition of the junction can take place in solution.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".