Acute net stressor increases whole-body cortisol levels without altering whole-brain monoamines in zebrafish.
Why this work is in the frame
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Bibliographic record
Abstract
Recent studies have started to examine the neurochemical and hormonal basis of behavior in zebrafish by examining biological correlates postmortem. However, it is unknown whether stress involved with experimental handling prior to euthanizing animals will have an impact on subsequent biological measures. In the current study, we expose zebrafish to a short net handling stressor (30 s) and examine the levels of monoamine neurotransmitters (dopamine, serotonin, and their metabolites) and whole-body cortisol at different intervals poststressor (0, 1, 5, 10, and 15 min). We report a time-dependent increase in the levels of cortisol, but no alterations in the levels of dopamine, DOPAC (dopamine's metabolite), serotonin, or 5HIAA (serotonin's metabolite) poststressor. The results demonstrate cortisol levels are more responsive to this type of stimulus compared with neurochemical measures.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it