Increase in uptake of peptide modified gold nanoparticles (GNPs)
Bibliographic record
Abstract
The interactions of synthetically produced gold nanoparticles (GNPs) with living organisms are getting attention in the biomedical sciences. While non-viral carriers, like GNPs, are safer and more cost-efficient than viral vectors, the efficiency of cell penetration is lower. Unmodified GNPs enter the cell through a receptor-medicated endocytosis (RME) and is encapsulated inside a double membrane endosome, which leads to exocytosis. Increasing uptake of GNPs into the cell is a challenging task as the GNPs has to escape the regular endo-lyso pathway. In this paper, various modifications using peptide conjugates have been performed to the GNPs to increase the efficiency of cell penetration. Quantitative and qualitative data are obtained from a UV spectrometer, an Atomic Absorption spectrometer, and Transmission Electron Microscope.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".