QVA149 zeigt signifikante Verbesserungen in Lungenfunktion und Gesundheitsstatus sowie gute Verträglichkeit gegenüber Glycopyrronium und Tiotropium bei Patienten mit schwerer COPD: Die SPARK-Studie
Bibliographic record
Abstract
Einleitung: QVA149 ist eine zugelassene, einmal täglich anzuwendende Bronchodilatator-Kombination aus Indacaterol (IND) und Glycopyrronium (GLY) zur Dauerbehandlung von Patienten mit symptomatischer COPD. Ziel der folgenden Analyse der SPARK-Studie war die Untersuchung des Effekts von QVA149 gegenüber GLY und Tiotropium (TIO) auf Lungenfunktion, Gesundheitsstatus und Sicherheit in der Subgruppe von Patienten mit schwerer COPD.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".