Myeloid sarcoma of the duodenum: a rare cause of bowel obstruction and gastrointestinal bleeding
Bibliographic record
Abstract
A 78-year-old man with known relapsing acute myeloid leukemia (AML) presented to the emergency department with a 24-hour history of vomiting. On arrival, he had evidence of coffee ground emesis, his heart rate was 115 beats/minute, and his blood pressure was 135/89 mmHg. A computed tomography (CT) scan of the abdomen performed to rule out gastric outlet obstruction revealed an obstructive mass occupying the fourth part of the duodenum ([ Fig. 1 ]). On enteroscopy, the mass was found to be friable, measuring 5 cm in diameter and occupying 75 % of the duodenal circumference ([ Fig. 2 ]). The lesion bled on contact and on taking biopsies, but the bleeding was controlled by application of the hemostatic powder TC-325 (Hemospray; Cook Medical, Winston-Salem, North Carolina, USA). Fig. 1 Computed tomography (CT) scan of the abdomen showing an obstructive luminal mass in the fourth part of the duodenum. Fig. 2 Enteroscopy images of a friable mass occupying the fourth part of the duodenum. Histology showed total replacement of the tissue in the biopsy by medium atypical blast-like cells consistent with myeloid sarcoma ([ Fig. 3 ]), as per the WHO classification, 2008. After a discussion with the oncologist, the patient opted for palliation without further active treatment. Fig. 3 Light microscopy of a biopsy that revealed duodenal myeloid sarcoma showing: a a monotonous population of medium-sized blasts with finely divided chromatin, small or inconspicuous nuclei, a small to moderate amount of cytoplasm, and indistinct cell membranes on a hematoxylin and eosin (H&E)-stained section (magnification × 800); b strong membranous staining with immunohistochemical staining for CD43 (magnification × 400; similar staining was observed for CD45); c overall variable moderate cytoplasmic staining with immunohistochemical staining for lysozyme (magnification × 400). Myeloid sarcoma is the extramedullary manifestation of AML, causing discrete tumor masses rather than diffuse infiltration. It occurs in the skin, lymph nodes, gastrointestinal tract, testis, or bone, and may occur prior to, concurrent with, or following a diagnosis of AML or another myeloproliferative disorder [ 1 ] [ 2 ]. Involvement of the duodenum is rare, with only eight cases reported in the literature and with most patients presenting with either abdominal pain or bowel obstruction [ 3 ]. Although bleeding arising from myeloid sarcoma has been reported in other parts of the gastrointestinal tract, to our knowledge, this represents the first reported case of a duodenal myeloid sarcoma presenting with upper gastrointestinal bleeding (UGIB). In addition, this report demonstrates the successful application of TC-325, a promising hemostatic powder, in the management of UGIB due to malignancy [ 4 ]. Clinicians should keep in mind this rare entity when approaching a patient with bowel obstruction or UGIB, particularly in the presence of a myeloproliferative disorder. Endoscopy_UCTN_Code_CCL_1AB_2AZ_3AB
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.005 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".