New Nomenclature of Human ABC Transporter Genes.
Bibliographic record
Abstract
The HUGO Human Gene Nomenclature Committee recently developed a new system of nomenclature for the human ATP-binding cassette (ABC) family. Until now more than 40 human ABC-transporter genes have been identified and sequenced. There is accumulating evidence that human ABC proteins are involved in transport of drugs, endogenous substances or ions. It has also been reported that mutations of certain ABC genes result in genetic diseases. Based on the arrangement of molecular structure components, i.e. nucleotide binding domains and topologies of transmembrane domains, hitherto reported human ABC proteins are classified into 7 different sub-families (A to G). The new nomenclature scheme was implemented on October 22, 1999, and detailed information is available on the web site at URL: ‹http://www.gene.ucl.ac.uk./users/hester/abc.html ›. (Nomenclature editor, Dr. Hester Mary Wain, University College London, U.K.).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.005 | 0.005 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.004 |
| Insufficient payload (model declined to judge) | 0.019 | 0.020 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".