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NEURO/MEDICAL ONCOLOGY
Prakash Ambady, Matthias Holdhoff, Cássio Ricardo Auada Ferrigno, S. Grossman, Mark D. Anderson, D. Liu, C. Conrad, Marta Peñas-Prado, M. R. Gilbert, Alfred Yung, J. de Groot, Tomokazu Aoki, Ryo Nishikawa, Kazuhiko Sugiyama, N. Nonoguchi, Noriyuki Kawabata, Kazuhiko Mishima, J.-i. Adachi, Kota Kurisu, F. Yamasaki, T. Tominaga, Tsutomu Kumabe, Keisuke Ueki, Fumi Higuchi, Takeyuki Yamamoto, Eisei Ishikawa, Hideo Takeshima, Shinji Yamashita, Kazunori Arita, H. Hirano, Satoshi Yamada, M Matsutani, Vinothini Apok, Samuel Mills, C. Soh, Konstantina Karabatsou, A. Arimappamagan, Sneha Arya, M.A. Majaid, Sampath Somanna, Vani Santosh, Lauren Schaff, F. Armentano, C. M. Harrison, Andrew B. Lassman, Guy M. McKhann, Fábio M. Iwamoto, Ying Yuan, Alvina Acquaye, E. Vera-Bolanos, Kristin Diefes, Lindsey Heathcock, Daniel P. Cahill, K. Aldape, Isabel Arrillaga‐Romany, KJ Ruddy, Steven A. Greenberg, L. Nayak, N. Avgeropoulos, George Avgeropoulos, Garrett Riggs, C.M. Reilly, Nilanjana Banerji, Peter J. Bruns, M. Silvija Hoag, Kathryn L. Gilliland, John Trusheim, Lien Bekaert, Alin Borha, Évelyne Emery, A Busson, J.-S. Guillamo, Muyinatu A. Lediju Bell, E. Sander Connolly, A. Khandji, J. O. Blakeley, X. Ye, Amanda L. Bergner, Eva Dombi, C. Zalewski, K. Follmer, Christopher F. Halpin, Laura M. Fayad, Matthew R. Jacobs, A. Baldwin, Shannon Langmead, Tiffany Whitcomb, Danna Jennings, B. C. Widemann, Warren Mason, J. Pichler, Adrian Nowak, M. Gil, F. Saran, Cédric Révil, Beatrix Lutiger, Bojana Milojkovic-Kerklaan, P. Aftimos, Sevilay Altıntaş, Agnes Jager, W. Gladdines, Fredrik Lönnqvist, Patricia M.M.B. Soetekouw, Myra van Linde, Adnan Awada, Jan H.M. Schellens, Dieta Brandsma, Andrew Brenner, Jingjing Sun, J. Floyd, Charles P. Hart, Charis Eng, Lisa Fichtel, Aleksandra Gruslova, Alessia Lodi, Stefano Tiziani, Carly A. Bridge, A. Baldock, P. Kumthekar, P. Dilfer, S. K. Johnston, Jerry C. Jacobs, D. Corwin, Laura Guyman, Russell C. Rockne, Adam M. Sonabend, Michael Cloney, Peter Canoll, J. Bromberg, H. Schouten, Ron Schaafsma, Joke W. Baars, Pieternella J. Lugtenburg, C. van Montfort, Jeanette K. Doorduijn, A. Spalding, R. V. Larocca, Diana M. Haninger, Tanuj Saaraswat, L. Jean Coombs, N. Shesh, Eric Burton, Stanisław R. Burzyński, A. Marszałek, T. Janicki, G. Burzynski, David Cachia, Thomas G. Smith, Andrés F. Cardona, L. C. Mayor, E. Jiménez, Fernando Hakim, Carlos Augusto Yepes, Nicolás Useche, J. L. Asencio, Jorge Otero, León Darío Ortiz, Hernán Carranza, Celibell Vargas, Andrés Quintero, Carlos E. Restrepo, Sobeyda Gomez, L. Bernal-Vaca, Mauricio Lema, C. Vargas, Maria I. Carlo, A. Omuro, Christian Grommes, Mark G. Kris, Christopher C. Nolan, Elena Pentsova, Maria C. Pietanza, Giorgio Carrabba, Lorenzo Giammattei, Riccardo Draghi, V. Conte, Ida Martinelli, Marco Locatelli, Paolo Rampini, Andrea Artoni, Filippo Cogiamanian, Gianluca Ardolino, Barbara Zarino, M. Chamberlain, Riccardo Soffetti, Roberta Rudà, Willem Boogerd, S. Taillibert, E. Le Rhun, Kurt A. Jaeckle, Olivier Chinot, Wolfgang Wick, Roger Henriksson, Khê Hoang‐Xuan, P. Kavan, Dana Cernea, Magalie Hilton, Yannick Kerloëguen, A. Guijarro, Timothy Cloughsey, Jai Ho Choi, Y.-K. Hong, W.K. Alfred Yung, John DeGroot, Mark R. Gilbert, Monica Loghin, I. Tremont, Simone Silberman, Donald Picker, Rui M. Costa, Jennifer L. Lycette, S. Gancher, John D. Cullen, Eric P. Winer, F. Hochberg, George Sachs, S. Jeyapalan, S. Dahiya, Graham Stevens, D. Peereboom, Manmeet S. Ahluwalia, M. Daras, Meier Hsu, Thomas Kaley, K. Panageas, Richard Curry, Eva E. Ávila, M de la Fuente, Lisa M. DeAngelis, Annick Desjardins, J. Sampson, K. Peters, Gordana Vlahovic, Stevie Threatt, Jill Boylston Herndon, Susan Boulton, Denise Lally-Goss, Frances McSherry, Alan H. Friedman, D D Bigner, Matthias Gromeier, Morgan Prust, Jayashree Kalpathy–Cramer, P. Poloskova, Kourosh Jafari‐Khouzani, Elizabeth R. Gerstner, V. Villani, Valérie Vaccaro, Antonello Vidiri, Diana Giannarelli, F. Piludu, V. Anelli, C. Carapella, F. Cognetti, A. Pace, A. Flowers, Brendan D. Killory, M. Furuse, Shin Miyatake, S. Kawabata, T. Kuroiwa, Pedro Garciarena, J. Hamilton, Dawid Schellingerhout, Gregory N. Fuller, Raymond Sawaya, S. Pugh, Minhee Won, Deborah T. Blumenthal, Michael Vogelbaum, A. Chakravarti, Robert Jeraj, James J. Dignam, J. S. Wefel, Paul D. Brown, D. Brachman, Maria Werner‐Wasik, Ivo W. Tremont‐Lukats, Erik P. Sulman, Bradley Gill, J. Yun, Hannah E. Goldstein, H. Malone, David J. Pisapia, G. K. Mckhann, Michael B. Sisti, Peter Sims, J. N. Bruce, Allicia C. Girvan, Gillian Carter, Li Li, Anna Kaltenboeck, Ayesha T. Chawla, Jasmina I. Ivanova, M. Koh, June Stevens, Michael Lahn, M. Gore, S. Hariharan, Camillo Porta, G. Bjarnason, Sergio Bracarda, Robert C. Hawkins, Stéphane Oudard, Kai Zhang, Kolette D. Fly, Ewa Matczak, Cezary Szczylik, Rachel Grossman, Zvi Ram, M. H. Hamza, B. O’Brien, Jacob Mandel, Seunggu J. Han, A. Molinaro, Mitchel S. Berger, M. Prados, Susan M. Chang, Jennifer Clarke, N. Butowski, N. Hashimoto, Yasuyoshi Chiba, A. Tsuboi, Manabu Kinoshita, R. Hirayama, N. Kagawa, Yukio Oka, Yusuke Oji, H. Sugiyama, T. Yoshimine, A. Hawkins-Daarud, Pamela Jackson, Juan M. Sarmiento, Diana Ly, J. Jutla, Alicia Ortega, Christine Carico, H. J. Dickinson, S. Phuphanich, Jeremy Rudnick, C.N. Patil, Jim C. Hu, S. Iglseder, M. Nowosielski, Meinhard Nevinny‐Stickel, G. Stockhammer, Rajan Jain, L. Poisson, L. Scarpace, T. Mikkelsen, J. Kirby, John Freymann, Scott N. Hwang, D. Gutman, C. Jaffe, Daniel J. Brat, A. Flanders, Hongfei Wang, Jae‐Cheol Jo, B. R. Williams, Mark E. Smolkin, M. Wintermark, Mark E. Shaffrey, Tareq A. Juratli, Silke Soucek, Matthias Kirsch, Gabriele Schackert, A. Kakkar, Sharath Kumar, Umesh Bhagat, Ajay Kumar, Ashish Suri, Mohini Singh, M. Sharma, C. Sarkar, V. Suri, Igor J. Barani, Michael McDermott, L. Rogers, Damien C. Weber, Ondřej Kalita, Miroslav Vaverka, Lumír Hrabálek, Miloslava Zlevorová, Radek Trojanec, Marián Hajdúch, M. Kneblova, Jiří Ehrmann, Andrew A. Kanner, John L. Villano, S. Khatua, Shayani Dasgupta, Michael Rytting, Tribhawan S. Vats, David E. Sandberg, L. Foresman, Mark W. Kieran, Birgit Geoerger, Michela Casanova, Jennifer Chisholm, Isabelle Aerts, Éric Bouffet, SM Leary, Michael Sullivan, Simon Bailey, Kenneth S. Cohen, Stacey Kalambakas, Priya Deshpande, Eunju Hurh, T. J. McDonald, Darren Hargrave, Stewart Goldman, Dereck D. Amakye, Michelle Patton, Lucas Moreno, Chae‐Yong Kim, Tackeun Kim, J. H. Han, Y. J. Kim, I. A. Kim, Chang‐Ho Yun, Hee‐Won Jung, Johan A F Koekkoek, J.C. Reijneveld, Linda Dirven, T. J. Postma, M. J. Vos, J. J. Heimans, M. J. B. Taphoorn, S Koeppen, J. Hense, Xiao–Tang Kong, T. Davidson, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Delong Kong, Y.-L. Choi, Hyun‐Joo Seol, J.I. Lee, Dahye Nam, Marcel Kool, David Jones, Natalie Jäger, Paul A. Northcott, Thomas J. Pugh, Volker Hovestadt, Shirley L. Markant, Lourdes Adriana Esparza, Franck Bourdeaut, Marc Remke, Michael D. Taylor, Y.-J. Cho, Scott L. Pomeroy, Ulrich Schüller, A. Korshunov, Roland Eils, Robert J. Wechsler‐Reya, P. Lichter, Stefan M. Pfister, Regina Krel, Yana Krutoshinskaya, Arthur Rosiello, Roberta Seidman, A. Kowalska, T. Kudo, Y. Hata, T. Maehara, Vijay Patel, A. Rademaker, I. Helenowski, M. Mrugala, Kristin R. Swanson, S. Grimm, Silviya K. Meletath, Michael Bennett, V. A. Nestor, Karen Fink, Eunjung Lee, J. Drappatz, Samantha N. Hammond, Andrew D. Norden, Rameen Beroukhim, C. McCluskey, Kerrington D. Smith, S. Gaffey, Mary Gerard, S. Snodgras, Haley Leeper, Derek R. Johnson, João A.C. Lima, Emily K. Porensky, R. Cavaliere, Alex T.L. Lin, Jingjing Liu, James M. B. Evans, E. Leuthardt, Ralph G. Dacey, Joshua L. Dowling, A. Kim, Gregory J. Zipfel, R. Grubb, Judy Huang, C. Robinson, J. Simpson, Gerald P. Linette, M. Chicoine, D. Tran, Simon V. Liubinas, Giovanna M. D’Abaco, Bradford A. Moffat, Michael Gonzales, Federica Feleppa, Cameron J. Nowell, Alexander N. Gorelick, Katharine J. Drummond, Andrew Morokoff, Terence J. O’Brien, Andrew H. Kaye, Amal Melhem‐Bertrandt, Tanweer M. Zaidi, R Katz, K. Lupica, Ibrahima Ly, S. R. Hamilton, Robert Rostomily, Shlomit Yust‐Katz, M. Gilbert, Doreen Pachow, Nadine Kliese, Elmar Kirches, Christian Mawrin, Mairéad G. McNamara, Zarnie Lwin, Hong Jiang, Caroline Chung, Barbara‐Ann Millar, Arjun Sahgal, Normand Laperrière, W. P. Mason, Judit Megyesi, Fateme Salehi, Vanessa L. Merker, Katherine Slusarz, Sally‐Anne Francis, Scott R. Plotkin, Toshio Suzuki, E. Uchida, Toru Yanagawa, Yuko Watanabe, Kyoji Fukuoka, T. Yanagisawa, Kenji Wakiya, T. Fujimaki, A. Moiyadi, S. Kannan, E. Sridhar, T. Gupta, Prakash Shetty, R. Jalali, J. Alshami, Magali Lecavalier‐Barsoum, Marie‐Christine Guiot, Donatella Tampieri, T. Muanza, Motoo Nagane, K. Kobayashi, Nobuyuki Takayama, Y Shiokawa, Hiroyuki Nakamura, Keishi Makino, J.-i. Kuroda, N. Shinojima, Seiji Yano, J.-i. Kuratsu, Navya S. Nambudiri, I. Arrilaga, Ian F. Dunn, Rebecca D. Folkerth, Shao-Yu Chi, David A. Reardon, Antonio Omuro, H. Ian Robins, Ramaswamy Govindan, S. Gadgeel, Karen Kelly, James R. Rigas, Hans‐Joachim Reimers, S. Rosenfeld, Jennifer Garst, N. Ramnath, P. Wing, Mingjie Zheng, P. Urban, Riccardo Soffietti, David M. Peereboom, Nancy U. Lin, David R. Macdonald, Evanthia Galanis, Jonathan M. G. Perry, R. Stupp, Eric T. Wong, Glenn J. Lesser, J. Raizer, Lisa Doherty, S. Ruland, Keith L. Ligon, Nancy Ann Oberheim Bush, S. Kesari, Benjamin Scott, M. Ohno, Yukiya Narita, Y. Miyakita, Hideyuki Arita, Yuko Matsushita, Akihiko Yoshida, Shintaro Fukushima, Kimiko Ichimura, Soichiro Shibui, Takuma Okamura, Sadao Kaneko, A. Omuro, L. Taillandier, Hervé Ghesquières, Carole Soussain, Vincent Delwail, T. Lamy, R. Gressin, Sylvain Choquet, Pierre Soubeyran, J.-P. Maire, A. Benouaich-Amiel, Sophie Lebouvier-Sadot, Emmanuel Gyan, M. Barrie, Manuel Sánchez del Río, Alberto González-Aguilar, C. Houllier, M-L. Tanguy, Nina A. Paleologos, Peter Forsyth, David N. Louis, J. Gregory Cairncross, Matthew J. Matasar, Minesh P. Mehta, Craig H. Moskowitz, Craig S. Sauter, P. Opinaldo, Roy Torcuator, Jaime Mejia, C. M. Carapella, Ashit Patel, Jeffrey C. Allen, David T. Dicker, J. Sheehan, Wafik S. El‐Deiry, Michael Glantz, Elina Tsyvkin, Paula K. Rauschkolb, Min Young Lee, Alexendar R. Perez, John T. Norton, Hartmut Uschmann, A. Chamczuck, Majid Khan, Jonathan Fratkin, Rifaquat Rahman, K. Hempfling, Arun Rai, Jennifer Rifenburg, Ivan Alexander Reveles, Luca Bello, Antonella Castellano, Luca Bertero, Chiara Bosa, Elisa Trevisan, Marco Riva, Marina Donativi, Andrea Falini, Sam S. Dahr, A. García, H. Sasaki, Yuya Nishiyama, K. Yoshida, Yuichi Hirose, M.E. Schwartz, Sherese Fralin, L. Rice, A. Drawz, Alfred Rademaker, K. Schwartz, Hye‐Sook Chang, Michele Nikolai, Peter C. Kurniali, Keith M. Olson, J R Pernicone, Charla Sweeley, Mary Noel, Rohan Gupta, Ichiyo Shibahara, Y. Sonoda, Ryuta Saito, Masayuki Kanamori, Yoshiaki Yamashita, Masato Watanabe, Hidekazu Suzuki, Takashi Watanabe, C. Ishioka, Kent C. Shih, Sajeel Chowdhary, Paul Rosenblatt, Alva B. Weir, G. Shepard, Joseph Williams, Mythili Shastry, John D. Hainsworth, Samuel Singer, Gregory J. Riely, M. G. Kris, Merideth Sanders, Yunus Arik, Tatjana Seute, Pierre A. Robe, Frans S. S. Leijten, Tom J. Snijders, Laura Sturla, J. J. Culhane, John K. Donahue, B. Suchorska, Nathalie Jansen, Vera Wenter, Sabina Eigenbrod, C. Schmid-Tannwald, Andreas Zwergal, Maximilian Niyazi, Peter Bartenstein, Oliver Schnell, Friedrich-Wilhelm Kreth, J.-C. Tonn, B. Wittwer, Marie Blonski, G. Faure, Mamede de Carvalho, Kazuhiro Tanaka, T. Sasayama, Masamichi Nishihara, Katsu Mizukawa, Eiji Kohmura, Simon Taylor, Kathy L. Newell, Lyn Graves, Marco Timmer, Christina K. Cramer, Gabriele Röhn, R. Goldbrunner, Sophia Turner, Thomas Gergel, Magali Lacroix, Steven A. Toms, Setsu Sakamoto, Philip Kim, María Ángeles Vaz Salgado, Ana Gómez Rueda, L. Ley, Mercedes García Villanueva, Juan Martínez San Millán, E. R. Cervantes, R. A. Pampliega, M Pedro, Víctor Rodríguez Berrocal, Alfredo Carrato Mena, Sander Veldhuyzen van Zanten, Michaela Jansen, Dannis G. van Vuurden, Marc C. Huisman, O. Hoekstra, Guus A.M.S. van Dongen, G. J. Kaspers, Annika Schlamann, André O. von Bueren, Christian Hagel, Christof M. Kramm, Rolf‐Dieter Kortmann, C. Friedrich, Klaus Müller, Katja von Hoff, Robert Kwiecien, T. Pietsch, N. U. Gerber, Peter Hau, J. Kuehl, Stefan Rutkowski, Joan L. Walker, Paula Warren, Stéphanie Robert, A. Lahti, Daniel White, Michelle Reid, Burt Nabors, Harald Sontheimer, I. Mellinghoff, K. Lamborn, S. Ramkissoon, S. Chang, Cristian Massacesi, Emmanuelle DiTomaso, G. Elzinga, L. Barron, Jessica L. Bloom, Kenneth D. Swanson, E. T. Wong, William Ka Kei Wu, Arabinda K. Das, Howard A. Fine, Daniel J. Sargent, Woohyuk Yoon, Shengyu Yang, DongJin Chung, Sin‐Soo Jeun, Andrea Milbourne, Jeffrey S. Weinberg, Mary Frances McAleer, Nabil Ahmed, Adriana Olar, John Stewart
Bibliographic record
VenueNeuro-Oncology · 2013
Typearticle
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsnot available
FundersInstitut Gustave-RoussyHospital for Sick ChildrenChildren's Healthcare of AtlantaSeattle Children's Research InstituteSidney Kimmel Comprehensive Cancer CenterNovartis Pharmaceuticals CorporationJohns Hopkins University
KeywordsMedicineMedical physicsInternal medicineOncology
Abstract
BACKGROUND: The treatment of patients with primary CNS lymphomas (PCNSL) has dramatically changed since the 1970's when whole brain radiation generated median survivals of about 12 months, significant neurotoxcity, and few long term survivors. High dose methotrexate (HD-MTX) monotherapy without radiation provides excellent response rates and 30% long term survivors without neurotoxicity. In general, relapses occur in the first two to four years after diagnosis and reports of very late relapses are rare. METHODS: Charts of all patients treated with HD-MTX monotherapy for newly diagnosed PCNSL between 1995 and 2012 at The Johns Hopkins Hospital were reviewed retrospectively. Patients with less than 5 years of follow-up data were excluded. First relapses over 10 years from diagnosis were identified and reviewed. RESULTS: Long-term follow-up data was available for 37 patients treated with HD-MTX monotherapy during this period. Four of 37 (11%) survived disease free for .10 years from initial diagnosis and maintain their excellent clinical status. All received methotrexate (8 gm/ m 2 ) every two weeks until complete response and then monthly to complete one year of therapy. Two of these long survivors (50%) presented with new seizures 10.8 and 11.2 years after initial diagnosis. Imaging revealed recurrent intraparenchymal disease, re-biopsy confirmed PCNSL in one, and both responded very well to retreatment with high dose methotrexate and Rituximab. The other two patients remain relapse free 12 and 13.7 years after initial diagnosis. CONCLUSION: Very late relapses have occurred in 2 of 4 long term survivors. These observations suggest that PCNSL patients treated with HD-MTX who were considered "cured" may be at substantial risk for late recurrences. A concerted effort to follow patients with this rare disease is needed to determine the frequency of late recurrences. More information is needed to determine if the addition of rituximab or other therapies reduce late recurrence rates.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.569
Threshold uncertainty score0.997
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.024
GPT teacher head0.319
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
Study designNot applicable
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations8
Published2013
Admission routes1
Has abstractyes