426Association between pre-transplant Staphylococcus aureus colonisation and post-transplant S. aureus infection among cystic fibrosis lung transplant recipients
Bibliographic record
Abstract
Background. Cystic fibrosis (CF) patients are frequently colonized with Staphylococcus aureus. However the impact of S. aureus colonization on post-transplant outcome among CF patients undergoing lung transplantation is unknown. Methods. We conducted a 5-year retrospective cohort study of all CF patients undergoing lung transplantation to determine the impact of pre-transplant S. aureus infection on the incidence of S. aureus infection after transplantation. All patients were followed up to one year after transplantation. Results. In total, 74 patients with CF underwent lung transplantation at our center. Thirty-seven patients (50%) were colonized with S. aureus prior to transplantation, 26 (35%) with MSSA, 6 (8%) with MRSA and 5 (7%) with both MSSA and MRSA. Nineteen (26%) patients had post-transplant S. aureus respiratory infections, 10 (14%) of which were pneumonia, 6 (8%) bronchitis and 3 (4%) received therapy without meeting the CDC criteria for respiratory tract infection. In a univariable analysis, pre-transplant S. aureus colonization was associated with an increased risk for post-transplant S. aureus infection (OR 4.46, 95%CI1.30–15.41; p = 0.01). However, there was no difference in length of ICU or hospital stay. In a multivariable model controlling for age > 30, gender, pre-transplant Pseudomonas colonization, pre-transplant S. aureus colonization remained independently associated with an increased risk for post-transplant S. aureus infection (OR 4.4770, 1.34-16.54; p = 0.01). There was no evidence for a difference in mortality between patients with (2; 5.4%) and those without pre-transplant S. aureus colonization (3; 8.1%) (p = 0.64). Conclusion. Our study suggests that pre-transplant S. aureus infection among CF patients undergoing lung transplant increases the risk of post-transplant S. aureus infection but does not negatively impact on post transplant one year survival. Disclosures. All authors: No reported disclosures.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".