Conductometric Titration Method for Determination of Alfuzosin Hydrochloride and Fexofenadine Hydrochloride Using Sodium Tetraphenylborate
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Bibliographic record
Abstract
A simple, precise and low cost conductometric method for the determination of alfuzosin hydrochloride and fexofenadine hydrochloride in pure form and pharmaceutical formulations using sodium tetraphenylborate has been described. The method is based on the formation of ion association complex of cations coming from the cited drugs with tetraphenylborate anions and the conductance of the solution is measured as a function of the volume of titrant. Various experimental conditions were evaluated. The described procedures allowed the determination of the studied drugs in double distilled water in the range of 2.13 - 10.65 and 2.50 - 13.45 mg of alfuzosin hydrochloride and fexofenadine hydrochloride, respectively. Statistical treatment of the experimental results indicates that the method is precise and accurate. The accuracy of the method is indicated by the excellent recovery 99.85-102.49 and 99.80-100.48% for alfuzosin hydrochloride and fexofenadine hydrochloride, respectively, and the precision is supported by the low relative standard deviation < 3.04%. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to potentiometric pharmacopoeial methods.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it