Аллельные формы гена бета-цепи интегрина как фактор генетической предрасположенности к некоторым гинекологическим заболеваниям
Bibliographic record
Abstract
Integrin receptors defects cause genetic predisposition to series of diseases such as myocardial infarction, myo-cardial ischemia, arterial and venous thrombosis, Glanzmann thrombasthenia, late gestosis and delay in fetus development. One of the integrins, glycoprotein Ilia (GPIIla) is known to be presented with two allelic forms, PLA1 and PLA2. We analyzed the frequency of these alleles among patients with uterus myoma, internal endometriosis and their combination, and obstetric bleeding. We have shown that presence of the defective allele PLA2 of the GPIIla gene in the female genotype is not a factor of genetic risk for development of uterus myoma. However, allele PLA2 in the female genotype considerably reduces the risk of development of internal endometriosis or internal endometriosis and uterus myoma together. Besides, the frequency of obstetric bleeding increases among the PLA2 allele carriers.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.010 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".