Bibliographic record
Abstract
It has recently been established that the activity of crystalline muscle phosphoglucomutase can be greatly stimulated by preincubation of the enzyme with a Mg++-imidazole complex. This observation has aroused interest in the physiological significance of such a system in the possible cellular control of phosphoglucomutase activity. The present study constitutes, in part, an investigation of the properties of phosphoglucomutase from brain tissue. A procedure for the purification of phosphoglucomutase from beef brain is described. The brain enzyme appears to be similar to that from skeletal muscle. Evidence is also presented which indicates that the "activation" produced by Mg++-imidazole is probably of no physiological importance in brain. This observation is consistent with the more recent reports that the phosphoglucomutase reaction is likely not involved in cellular regulatory mechanisms. It is well established that phosphofructokinase is intimately involved in the cellular regulation of glycolysis and the citric acid cycle. Control mechanisms of the phosphofructokinase reaction in mammalian tissues have been postulated on the basis of the complex kinetics of the enzyme. In yeast, however, two enzymatically interconvertible forms of the enzyme have been reported. Preliminary experiments in this study failed to demonstrate a phosphofructokinase system in brain similar to that found in yeast.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".