Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages
Bibliographic record
Abstract
ABSTRACT Skeletal muscles arise from diverse embryonic origins, yet converge on common regulatory programs involving muscle regulatory factor (MRF)-family genes. Here, we compare the molecular basis of myogenesis in two separate muscle groups in the simple chordate Ciona: the a trial and o ral s iphon m uscles. Here, we describe the ontogeny of OSM progenitors and characterize the clonal origins of OSM founders to compare mechanisms of OSM specification to what has been established for ASM. We determined that, as is the case in the ASM, Ebf and Tbx1/10 are both expressed and function upstream of Mrf in the OSM founder cells. However, regulatory relationships between Tbx1/10, Ebf and Mrf differ between the OSM and ASM lineages: while Tbx1/10, Ebf and Mrf form a linear cascade in the ASM, Ebf and Tbx1/10 are expressed in the inverse temporal order and are required together in order to activate Mrf in the OSM founder cells.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".