Inflammatory bowel disease in pediatrics.
Bibliographic record
Abstract
Crohn’s disease (CD) Crohn’s disease (CD) Crohn’s disease (CD) Crohn’s disease (CD) Crohn’s disease (CD) and ulcerative colitis (UC) are chronic diseases characterized by unpredictable periods of disease activity and quiescence. Some patients suffer from almost continuous symptoms, others, only rare flares of disease activity. In addition to affecting the daily lives of patients, these diseases can dramatically alter family functioning and the patient’s opportunity for becoming a productive adult. As difficult as it may be to manage adults with the disease, the problem of managing childhood disease is made more challenging by children’s growth, their emotional and social development, and the knowledge that even after 30 years of complications of the disease and therapies, pediatric patients may just be entering the prime of their productive years. The difficult task of eventually transitioning the adolescent to adult health care providers presents additional challenges. Current management practices are based on the use of old and new medications neither rigorously tested nor approved for use in children. In an effort to better define the contemporary natural history of IBD in children and augment current management practices, the Pediatric Inflammatory Bowel Disease Research Registry was established in 2002. Initially a collaboration of 21 centers in the US and Canada, this registry has produced several important advances in our understanding of IBD in children. Much of that research is reported in this review. The focus of this paper is to review current advances in pediatric IBD and to emphasize the need for more prospective research.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.053 | 0.018 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".