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Record W2341921501 · doi:10.2741/4387

Heme oxygenase in cardiac repair and regeneration

2015· review· en· W2341921501 on OpenAlex
Joseph Fomusi Ndisang

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueFrontiers in bioscience · 2015
Typereview
Languageen
FieldMedicine
TopicCardiac Structural Anomalies and Repair
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsHeme oxygenaseRegeneration (biology)Heart failureMyocardial infarctionHemeRegenerative medicineMedicineCardiac function curveApoptosisNecrosisStem cellCell biologyCardiologyInternal medicineBiologyBiochemistryEnzyme

Abstract

fetched live from OpenAlex

The incidence of cardiac complications such as myocardial infarction and congestive heart failure is increasing. Once congestive heart failure emerges, little can be done to improve long-term cardiac function. The cellular basis of this downward spiral may be the dramatic loss of viable cardiomyocytes following acute ischemia and/or chronic apoptosis/necrosis which are not adequately replaced. Contrary to the old postulates of developmental biology, tissue self-renewal is not limited to blood, intestines and skin, but other organs including the heart have some capabilities of self-renewal. However, the intrinsic ability of self-renewal of adult myocardium or cardiomyogenesis is limited and thus novel paradigms capable of potentiating this process of regenerative organogenesis should be sought. Several strategies and paradigms are being currently explored, and among these is the heme-oxygenase system. Emerging evidence indicate that the heme-oxygenase system could be explored in regenerative medicine given its unique ability to concomitantly suppress apoptosis and necrosis, while facilitating tissue regeneration/repair and the formation of new blood vessels. This review highlights the recent development of heme-oxygenase in myocardial repair and regeneration.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.965
Threshold uncertainty score0.723

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.030
GPT teacher head0.311
Teacher spread0.281 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it