Domiciliary exhaled nitric oxide and eosinophilic airway inflammation in adults with asthma
Bibliographic record
Abstract
Sputum eosinophils are the gold standard measure of eosinophilic airway inflammation and there is strong evidence that titrating corticosteroid therapy to sputum eosinophils reduces the rate of asthma exacerbations [1]. However, this measurement is time consuming and requires specific technical expertise. Exhaled nitric oxide ( F eNO) is a noninvasive surrogate marker of eosinophilic airway inflammation that may be measured using small portable devices. Studies of using F eNO to titrate therapy have yielded mixed results [2, 3]. However, it is possible that one-off clinic readings may not be the best method of utilising F eNO, and the home monitoring potential of F eNO has not yet been fully explored. Exhaled nitric oxide home monitoring is a promising surrogate marker of eosinophilic airway inflammation in asthma
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.010 | 0.007 |
| Insufficient payload (model declined to judge) | 0.005 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".