SP307VITAMIN D SUPPLEMENTATION IS ASSOCIATED WITH IMPROVED MODULATION OF CARDIAC AUTONOMIC TONE IN IGA NEPHROPATHY
Bibliographic record
Abstract
Introduction and Aims: Vitamin D deficiency and cardiovascular autonomic dysfunction, both strongly associated with cardiovascular risk, are common in the kidney disease population. Though we have previously shown that vitamin D supplementation is associated with normalization in cardiac autonomic tone in healthy humans, this relationship in the setting of kidney disease is not understood. Methods: Fifteen subjects (87% male, 41±4yrs) with IgA nephropathy (estimated glomerular filtration rate 101±7ml/min/1.73m2; proteinuria 1.03g/24h) were studied pre- and post-28d of high-dose oral vitamin D3 supplementation (cholecalciferol, 10,000 IU/day). Cardiac autonomic tone, quantified by power spectral analysis of heart rate variability [low-frequency power, high-frequency power, and overall cardiosympathetic/parasympathetic balance], was measured at baseline and in response to graded angiotensin II challenge pre- and post- vitamin D3 supplementation. Results: Both 25-hydroxy vitamin D (63±7 vs 136±12 nmol/L, p<0.001) and 1,25 dihydroxyvitamin D (107±9 vs 126±13 pmol/L, p=0.14) levels increased but no changes in baseline measures of cardiac autonomic tone were observed. However, vitamin D3 supplementation was associated with an improvement in the cardiac autonomic responses to AngII challenge, particularly associated with an increase in cardioprotective parasympathetic activity throughout the stressor which was most strongly observed in those subjects with the highest levels of 1,25-dihydroxy vitamin D (Figure 1).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".