Soluble IL-7 receptor (sCD127) in pediatric HIV infection (57.9)
Bibliographic record
Abstract
Abstract IL-7 is an essential cytokine in T-cell development and homeostasis. It binds to the IL-7R receptor, a complex of the IL-7Rα (CD127) and common γ (CD132) chains. There is significant interest in evaluating the expression of CD127 on human T-cells as it often decreased in medical conditions leading to lymphopenia. A soluble CD127 (sCD127) is released in plasma and may contribute to disease pathogenesis through its control on IL-7 activities. We determined the concentrations of soluble CD127 in plasma of children infected with HIV using a quantitative bead-based sCD127 immunoassay. Eleven children were followed over a period of up to two years. The sIL-7R detected in HIV infected children ranged from 66 to 1004 ng/mL. Individual sCD127 concentrations remained stable when measured serially during a period of up to two years in five children with low viral load (HIV RNA 50-500 copies/mL). In children with uncontrolled viral load (n=6) (HIV RNA 50-137 000 copies/mL), the concentrations of sCD127 varied by up to 4 fold.This is the first report on the quantification of plasma sCD127 in pediatric HIV infection. The concentrations of sCD127 in children varied by up to one log. We previously reported a similar variation among adult sCD127 concentrations. The stability of the sCD127 concentrations in children with low viral load and the variations observed in children with uncontrolled viral load warrant further studies on the sCD127 as a potential marker of T cell homeostasis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".