Bibliographic record
Abstract
This project was undertaken to obtain more information about the nature of the water-soluble metabolites formed by rat liver since these had been shown to differ from the normal conjugates found in other species and are influenced by the sex of the animal and also by compounds in the soluble fraction of the cell. A comparison was made between these products and those formed from estrogens by mushroom phenolase under similar conditions, and it was found that glutathione had the same effect as the soluble fraction of the cell in increasing the yield of water-soluble metabolites in the rat liver microsomal system. This tripeptide also competed effectively with protein-binding and proposals to account for this reaction have been put forward. A marked increase in the yield of water-soluble estrogen derivatives was also observed when glutathione was added to the phenolase system, and although a different mechanism may be involved, similar types of products were formed. A competitive reaction for protein-binding in the presence of glutathione was again demonstrated. Sulphydryl compounds such as cysteine, ergothionine, homocysteine and thiolhistidine had little or no effect in either of the two systems, and the reaction therefore appears to be specific for glutathione. Oxidized glutathione was ineffective in increasing the yield of water-soluble metabolites indicating that the sulphydryl group was involved, and N-ethylmaleimide was found to be strongly inhibitory. The effect of estrogen oxidation products on the in vitro inactivation of gonadotropins was also investigated.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".