Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
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Abstract
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.
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The record
- Venue
- Science
- Topic
- Gut microbiota and health
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- Centre for Global Health Research
- Funders
- National Institute of Diabetes and Digestive and Kidney DiseasesSeventh Framework ProgrammeNederlandse Organisatie voor Wetenschappelijk OnderzoekH2020 European Research CouncilSeres Therapeutics
- Keywords
- MetagenomicsGut microbiomeMicrobiomeBiologyFecesGut floraPopulationComposition (language)ZoologyComputational biologyEcologyBioinformaticsImmunologyGeneticsMedicineGeneEnvironmental health
- Has abstract in OpenAlex
- yes