The characteristics of vascular cognitive impairment no dementia in patients with cerebral small vessel disease and the evaluation of nimodipine treatment
Bibliographic record
Abstract
Objective To explore the neuropsychological difference of vascular cognitive impairment no dementia in two subtpyes of cerebral small vessel disease(SVD) patients and to evaluate the therapeutic effects of nimodipine on the disease.Methods A total of 118 SVD patients,including 52 Lacunar Infarction(LI) and 66 White Matter Lesion(WML) patients,were enrolled.The patients were divided into experimental group and control group randomly.The patients in the experimental group were treated with nimodipine 90 mg/d for six months,combined with basic treatment;while the control group just got basic treatment.Before and after the treatment,the neuropsychological evaluations were performed with mini-mental state examination(MMSE),montreal cognitive assessment(MoCA),semantic category verbal fluency test(animals),stroop test(calculation mistakes),Chinese version of Wechsler adult intelligence scale(block design,digit span,digit sign),clock drawing test,and Webster's memory scale(logic and memory test,regeneration test).The neuropsychological characteristics in LI and WML patients,the scores of cognitive impairment assessment before and after the treatment were compared with t tests.Results Before the treatment,the scores of semantic category verbal fluency test(animals),digit sign,logic and memory test,regeneration test,MoCA,and MMSE were higher,and the scores of stroop test were lower in LI patients than in WML patients.After six-month treatment,the scores in all the tests did not show significant change in control group(P0.05).However,after the treatment of nimodipine in experimental group,the scores of MoCA,clock drawing test,and digit span increased,while the scores of stroop test decreased significantly in LI patients(P0.05).In WML patients,the scores of MoCA,MMSE,clock drawing test,digit span,and regeneration test elevated,while the scores of stroop test declined significantly(P0.05).Conclusions The degree of vascular cognitive impairment no dementia is different between the two subtypes of SVD,and the cognitive impairment in LI patients is not as severe as that in WML patients.Nimodipine is effective in the treatment of vascular cognitive impairment no dementia in SVD patients mainly because it helps to improve the executive function,space structure capacity,and attentiveness.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".