The Significance of Thrombin Activable Fibrinolysis Inhibitor in Ischemic Stroke
Bibliographic record
Abstract
Background : Thrombin/thrombomodulin complex activates thrombin activable fibrinolysis inhibitor (TAFI) to active TAFI (TAFIa), which in turn catalyzes the hydrolysis of C-terminal lysine residues of partially degraded fibrin. The fibrin that is partially degraded by TAFIa is not degraded by plasmin. Thus, TAFI inhibits fibrinolysis. An increase in plasma TAFI level is suggested to be associated with thrombotic disorders. In this study, we measured TAFI levels and investigated the distribution of C+1542G polymorphism in Korean patients with ischemic stoke. And, we intended to investigated the role of TAFI in the occurrence of ischemic stroke. Methods : We enrolled 44 patients who had experienced ischemic stroke episodes more than 6 month ago and had not been treated with oral anticoagulant. We also tested 44 age and sex-matched healthy controls. TAFI antigen levels were measured by an enzyme-linked immunosorbent assay (Visulize TAFI antigen kit; Affinity Biologicals Inc., Ancaster, Canada) and TAFI activity levels were measured by a chromogenic assay (Actichrome TAFI activity kit ; American diagnostica Inc., CT, USA). Genotyping of C+1542G polymorphism was performed by an allele-specific polymerase chain reaction. Results : The range of TAFI antigen was 2.4-12.7 g/mL (mean2SD) and that of TAFI activity was 4.9-17.9 g/mL (mean2SD) in healthy controls. TAFI antigen level was not correlated with TAFI activity. TAFI activity was the highest in CC polymorphism and the lowest in GG polymorphism (P=0.03). The levels of TAFI antigen and activity were lower in the patients with ischemic stroke than in healty controls, but the difference was not statistically significant. There was no difference in the distribution of C+1542G polymorphism between the patients with ischemic stroke and healthy persons. Conclusions : In this study, TAFI antigen and activity were not significantly associated with the occurrence of ischemic stoke in Korean. And, TAFI may not be a risk factor for ischemic stroke in the Korean population.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".