Effects of Kidney-Supplementing Blood-Quickening Therapy on Bone Mineral Density,Bone Metabolism and the Incidence of Fragility Fractures in Primary Osteoporosis
Bibliographic record
Abstract
Objective To observe the therapeutic effect of kidney-supplementing blood-quickening therapy on Primary osteoporosis(OP).Methods Totally 240 cases of OP were randomized into the test group of 150 cases and control group of 90 cases.There were 50 patients with kidney-yang deficiency blood stasis pattern,50 patients with kidney-yin deficiency blood stasis pattern and 50 patients with spleen-kidney deficiency blood stasis pattern in the test group,and they were given Gusong Qianggu Formula(骨松强骨方),Gusong Jiangu Formula(骨松健骨方)and Gusong Yigu Formula(骨松益骨方)respectively.There were 30 patients with kidney-yang deficiency blood stasis pattern,30 patients with kidney-yin deficiency blood stasis pattern and 30 patients with spleen-kidney deficiency blood stasis pattern in the control group,and they were given Xianling Gubao Capsules.Both groups were treated for 12 weeks and followed up to the 48th week.The bone mineral density(BMD)and the levels of bone-specific alkaline phosphatase(BALP)and β-CrossLaps of type I collagen containing cross-linked C-telopeptide(β-CTX)were detected in both groups before and after treatment.The incidence of fragility fractures was observed before treatment and on the 48th week after treatment.Results The total efficacy of BMD in the patients with kidney-yang deficiency blood stasis pattern and spleen-kidney deficiency blood stasis pattern in the test group was 83.33% and 89.8% respectively,which was significantly higher than 50.00% and 37.93% in the control group(P 0.05).The β-CTX level and incidence of fragility fractures was significantly decreased in the test group after treatment(P 0.05 or P 0.01), especially in the patients with kidney-yang deficiency blood stasis pattern and spleen-kidney deficiency blood stasis pattern(P 0.05 or P 0.01).Conclusion kidney-supplementing blood-quickening therapy can effectively inhibit bone resorption,prevent decreased BMD and reduce the incidence of fragility fractures in primary OP patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".