Protective effect of keratinocyte growth factor on intestinal epithelial cell line No. 6 after irradiation
Bibliographic record
Abstract
Objective To study radioprotective effect and the mechanism of keratinocyte growth factor (KGF) on irradiation induced intestinal epithelial cell line No. 6 (IEC 6) in order to found a basis for KGF clinical application. Methods KGF was added to the culture medium of IEC 6 pre and post exposured to various doses of irradiation. Cell proliferation and percentage of apoptic cells were determined to indicate the radioprotective effect and cell radiation sensitivity of KGF. Results KGF exerted dose depended effect on the proliferation of normal cultured IEC 6 and the effect was significantly alleviated on that of the radiated IEC 6. The pre administration of KGF reduced the IEC 6 radiation sensitivity significantly and 50% inhibition dose of irradiation for cell proliferation (IP 50 ) was decreased from (15.3 ±0.6)Gy in non KGF treated group to (12.2±0.4)Gy in KGF treated group. Conclusion KGF possesses the effect of improving the proliferation of IEC 6 and its radioprotective effect might be due to the decrease of cell radiation sensitivity and the inhibition of the apoptosis of radiation reduced cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".