Research and Application of Biodegradable Polymer Containing Poly(lactic acid) in Preparation of Drug Loaded Microspheres or Microcapsules
Bibliographic record
Abstract
The research background and current status of biodegradable polymeric materials containing polylactic acid (PLA) for the preparation of the drug loaded microspheres or microcapsules are reviewed. The preparation methods of three different kinds of polymer materials are described in detail,including lactide ring-opening polymerization,polycondensation of lactic acid to prepare polylactic acid(PLA); copolymerization of lactide ring opening with glycolic acid to prepare poly(lactic acid-co-glycolic acid )copolymer (PLGA),polyethylene glycol monomethyl ether (mPEG) with lactide ring-opening or with lactic acid to prepare poly(lactic acid-co-polyethylene glycol monomethyl ether) diblock copolymer(mPEG-PLA).The microspheres' preparation and release mechanism and advantages of application in drug,especially polypeptide,micromocular proteins are also described. Main problems of application,especially the study and development in our country are introduced,and the prospect of these polymers is discussed.It's suggested that this kind of polymers will be one ofimportant drug delivery carrier of modern biological drug.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".