Effect of Rare Earth Ions on Kinetic Properties of Escherichia coli Leucyl-tRNA Synthetase
Why this work is in the frame
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Bibliographic record
Abstract
Escherichia coli leucyl tRNA synthetase (LeuRS) is one of aminoacyl tRNA synthetases (aaRSs) and belongs to class 1 aaRSs. The apparent steady state kinetics of the aminoacylation reaction catalyzed by LeuRS in the presence of some RE 3+ were studied. The results show that Mg 2+ can be substituted by RE 3+ for the aminoacylation reaction. The apparent K m values for ATP and leucine are markedly different between native and Mg 2+ free tRNA 1 Leu . At high concentration of ATP there is inhibitory effect on Mg 2+ free tRNA but not on native tRNA, which indicates that metal ions are a substrate of the aminoacylation reaction.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it