Bibliographic record
Abstract
ATP-binding cassette transporter A1 (ABCA1) is an important membrane transporter for cholesterol and lipids, it promotes overloaded cholesterol to efflux from cells to ApoA-I and package into high-density lipoprotein, which process involved in revise cholesterol transfer. In this study, we found the effect of transcription factor ATF6 on ABCA1 regulation in HEK293 cells. The results showed that ATF6 up-regulated ABCA1 transcriptional activity and protein expression in a dose-dependent manner. This regulation of ABCA1 by ATF6 was not through ER stress regulatory pathway. The analysis of promoter deletion and different function domain mutation revealed that responsive region to ATF6 located on the up stream of ABCA1 promoter within -156 to -928 and that the conserved E-box motif, but not DR4 motif, might be responsible for the ATF6-mediated ABCA1 promoter activation. Further, the in vivo study demonstrated that overexpression of ATF6(N) by adenovirus in the liver of C57 mice increased ABCA1 at mRNA levels, as well as ATF6 target gene.Thus, this study provides a novel function for ATF6 and the new mechanism of ABCA1 regulation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".