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Record W2356054575 · doi:10.1155/2006/726808

Extended‐Spectrum Beta‐Lactamases

2006· article· en· W2356054575 on OpenAlexaffabout
Kevin R. Forward

Bibliographic record

VenueCanadian Journal of Infectious Diseases and Medical Microbiology · 2006
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAntibiotic Resistance in Bacteria
Canadian institutionsQueen Elizabeth II Health Sciences Centre
Fundersnot available
KeywordsCephalosporinAntimicrobialMicrobiologyBacteriaBroad spectrumBiologyMedicineComputational biologyAntibioticsChemistryCombinatorial chemistryGenetics

Abstract

fetched live from OpenAlex

The definition of extended‐spectrum beta‐lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world. In Canada, the problem has grown less rapidly than in other parts of the world; however, ESBLs still present a significant impediment to the treatment of serious infections with extendedspectrum cephalosporins and penicillins. Although SHV‐derived enzymes were the primary concern in the late 1980s and early 1990s, these enzymes have been rapidly overtaken by the CTX‐M family of ESBLs. There is no reason to believe that the problem of ESBLs will not expand rapidly in the face of intense antimicrobial pressure and lapses in infection control practices. Control should focus on early detection, accurate characterization, effective treatment and measures to prevent further spread.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.007
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0070.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.002
GPT teacher head0.202
Teacher spread0.200 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations18
Published2006
Admission routes2
Has abstractyes

Explore more

Same venueCanadian Journal of Infectious Diseases and Medical MicrobiologySame topicAntibiotic Resistance in BacteriaFrench-language works237,207