A study of relationships between distribution of vesicular monoamine transporter in brain and PD
Bibliographic record
Abstract
Objective To investigate the distribution of vesicular monoamine transporter(VMAT2) in brain and their relationships with Parkinson disease(PD).Methods PD model of C57BL mice induced by reserpine,MPTP,reserpine plus MPTP was used respectively and human embryonic brains of different parts(substantia nigrapars compacta,SNC),ventral tegmental areas(VTA) and locus coeruleus(LC) were examined by immunohistochemistrical staining and Western blot.Results The number of VMAT2-positive neurons and the number of TH-positive neurons in SNC were significantly reduced in PD model than the control,but there was no great difference in VTA and LC between PD model and the control.The distribution of VMAT2 in the control and human embryonic brains in SNC was less than that in both VTA and LC.Conclusion The amount of VMAT2 that has protective effect on the DA neurons in SNC is less than that in both VTA and LC.The weakage of the protecting function of VMAT2 in SNC may be the important cause of the selective DA neurons loss.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".