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Record W2360159874 · doi:10.1038/ng.3572

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

2016· article· en· W2360159874 on OpenAlexafffund
Buhm Han, Jennie G. Pouget, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothée Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K. Gregersen, Solbritt Rantapää‐Dahlqvist, Jane Worthington, Javier Martı́n, Lars Klareskog, T. Huizinga, Wei‐Min Chen, Suna Önengüt-Gümüşcü, Stephen S. Rich, Naomi R. Wray, Soumya Raychaudhuri

Bibliographic record

VenueNature Genetics · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversity of TorontoCentre for Addiction and Mental Health
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesNational Human Genome Research InstituteNational Institute of General Medical SciencesNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Allergy and Infectious DiseasesMedical Research CouncilNational Institutes of HealthJuvenile Diabetes Research Foundation InternationalAsan Institute for Life Sciences, Asan Medical CenterNational Health and Medical Research CouncilFulbright CanadaNational Institute of Child Health and Human DevelopmentFondation Brain Canada
KeywordsPleiotropyBiologyGenetic heterogeneitySchizophrenia (object-oriented programming)Rheumatoid arthritisGenotypeAlleleGeneticsMajor depressive disorderImmunologyMedicinePsychiatryPhenotypeGeneEndocrinology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.734
Threshold uncertainty score0.947

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.295
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations70
Published2016
Admission routes2
Has abstractno

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