The hypoxic inhibitory effect on the activity of mitochondrial respiratory chain complex at rat gastrointestinal tissue
Bibliographic record
Abstract
To study the effect of hypoxia on the activity of mitochondrial respiratory chain complex and free radical metabolism in rat gastrointestinal tissue.Male Wister rats are exposed to hypoxia at the simulate altitude of 5 000 mat 4h,24 h,72hrespectively.Take the stomach and small intestine tissue as research objects,the mitochondrial respiratory chain enzyme complexes Ⅰ~Ⅳ activity,the mitochondrial superoxide dismutase(SOD)activity and malondialdehyde(MDA)content are tested by spectrophotometry.The results show that hypoxia exposure of the simulate altitude at 4hand 24 hsignificantly decrease the enzyme activity of mitochondrial respiratory chain of four kinds of complexes in gastrointestinal(P0.01)and the active level of these is recovered close to those of control group at the 72h(P0.05).The mitochondrial SOD activity at hypoxia treatment groups is significantly lower than the control group(P0.01)after hypoxia exposure and the content of MDA is higher than that of control group(P0.01)at gastrointestinal tissue.Therefore,the acute altitude hypoxia can inhibit the enzyme activity of rat gastrointestinal mitochondrial respiratory chain components and the effect may be relate to the directaction of hypoxia and oxidative stress damage thereby.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".