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Record W2361066353

Endo-glucanase gene homologous expressed in Aspergillus niger

2014· article· en· W2361066353 on OpenAlexaff
Ji Li

Bibliographic record

VenueDongbei Nongye Daxue xuebao · 2014
Typearticle
Languageen
FieldEngineering
TopicBiofuel production and bioconversion
Canadian institutionsScience North
Fundersnot available
KeywordsAspergillus nigerGlucanaseGeneBiologyMutantBiochemistryExpression vectorRecombinant DNA
DOInot available

Abstract

fetched live from OpenAlex

An endo-glucanase can truncate long chains of cellulose in cellulose non-crystalline region through random hydrolysis of β- 1, 4- glycosidic linkage, which plays an important role in the overall degradation of cellulose. In order to improve the endo- glucanase activity of Aspergillus niger, a gene designated Eng1 encoding an endo-glucanase from Aspergillus niger CICC2462 was cloned by using the reverse transcription PCR method. Using the highly expressed elment of glaA encoding a glucoamylase, the recombinant expression vector pSZHG-Eng1 was constructed and transformed into the strain CICC2462 via the Agrobacterium-mediated method. Two strains were obtained by screening hygromycin resistant mutants and base pair substitution based on homologous recombination was established by PCR to exist in glaA gene loci gene. Under the shaking flask fermentation condition, the endo-glucanase activity of the A.niger transformant reached 272 U· mL- 1in the fermentation solution, which was 5.2-fold as high as that of the original strain. The approximately 36 ku protein band from two strains was observed on the SDS-PAGE, and the expressed enzyme was quantitated to be 165- 193 μg · mL- 1. This results showed that the endoglucanase gene was successfully transformed and homologously expressed in Aspergillus niger, which laid the foundation for the construction of an engineered strain to produce a food-grade endo-glucanase in large scale industrial production.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.419
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.186
Teacher spread0.179 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes1
Has abstractyes

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