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Record W236254026

Cobalt, nickel and zinc-DNA interactions : a structural study

2003· article· en· W236254026 on OpenAlexfundno aff
Shaunivan Labiuk

Bibliographic record

VenueUniversity Library - University of Saskatchewan (University of Saskatchewan) · 2003
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDNA and Nucleic Acid Chemistry
Canadian institutionsnot available
FundersBasic Energy SciencesNational Center for Research ResourcesCanadian Institutes of Health ResearchOffice of ScienceNational Institutes of HealthUniversity of SaskatchewanU.S. Department of Energy
KeywordsNickelCobaltZincChemistryMetallurgyMaterials science
DOInot available

Abstract

fetched live from OpenAlex

M-DNA is a complex between DNA and cobalt(II), nickel(II) or zinc(II) that forms under alkaline conditions.It has been postulated that the imino proton of guanine or thymine is replaced by the metal cation in each base-pair.The complex is thought to maintain a double-helical structure similar to B-DNA but has unusual properties.M-DNA acts as an electron conductor making it a potential candidate for future nanotechnology applications.In this work the interactions of cobalt(II), nickel(II) and zinc(II) with DNA were studied.This was done in order to gain knowledge concerning the interactions of these metal cations with B-DNA and to assess aspects of the proposed M-DNA structural model.Firstly, experiments that demonstrated ionizing or ultraviolet radiation induced interstrand crosslinking in M-DNA are consistent with the hypothesis that M-DNA maintains a double-helical structure in which guanine

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.173
Teacher spread0.168 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2003
Admission routes1
Has abstractyes

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Same venueUniversity Library - University of Saskatchewan (University of Saskatchewan)Same topicDNA and Nucleic Acid ChemistryFrench-language works237,207