The relationship between the traffic of HTLV-1 across the blood-brain barrie r and thd mechanism of HAM/TSP
Bibliographic record
Abstract
Objective:To investigate the traffic of HTLV-1acrossing the bl oo d-brain barrier and viral entring into the CNS,in order to indicate the mechani sm of HAM/TSP.Methods:CSF mononuclear cells and peripheral blood mononuclear cel ls(PBMC)were collected from5patients with HAM/TSP.The amplification of HTLV-1i ntegration sites between CSF and PBMC was compared by Linker-mediated polymerase chain reaction(LMPCR).Results:Such oligoclonal distribution of HTLV-1-infecte d cells was evidenced in the cerebrospinal fluid(CSF)derived from5patients wit h HAM/TSP.Furthermore,clonal populations of HTLV-1-infected lymphocytes sharing the same HTLV-1proviral flanking sequences(i.e.,integration sites in the cell ular DNA)were found in both the CSF and the peripheral blood.Conclusion:HTLV-1c rosses the blood-brain barrier by migration of HTLV-1-infected lymphocytes in vi vo.The proliferation of infected cells will lead to pathogenic mecha-nisms of H AM/TSP.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".