Study on peptide vaccine Cop-I induces the specific immune response in MS patients
Bibliographic record
Abstract
Objective:To study on the immune response of patients with MS received Cop I for one year.Methods:The frequency of Cop I/MBP reactive T cell line was detemined by split well microtitre method.The cytokine profile of these T cells was quantitatively analyzed by ELISA.The phenotype of these T cell lines was assessed by immunofluroscence technique.Results:In 15 MS patients and 9 other neurologic diseases(OND)patients who received the Cop I for one year,the mean frequency of Cop I/MBP specific T cell lines was 84 0% and 5.4% respectively.The cytokine profile of Cop I specific T cell lines demonstrated the Th2 cytokines like IL 5 and IL 13.Further,all of the MBP/Cop I specific T cell lines were CD3 positive Cop I,most of them expressed CD8 and some of them were CD3/CD56 double positive cells called NKT,which only kill the Glioma cells but leave the K562 alive.Conclusion:These results indicate that Cop I can induce the specific immune response involved in mainly by CD8 and NKT cells.Meanwhile Cop I can upregulate Th2 cell in the T cell immune repertorie in the Cop I treating MS patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".