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Record W2365729577

Research Progress of OPA1

2014· article· en· W2365729577 on OpenAlexaff
Nie Wei-tia

Bibliographic record

VenueXiandai shengwu yixue jinzhan · 2014
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMitochondrial Function and Pathology
Canadian institutionsScience North
Fundersnot available
KeywordsMitochondrionApoptosisBiologymitochondrial fusionHeat shock proteinCell biologyInner mitochondrial membraneAtrophyHSP60MutantInner membraneFunction (biology)GeneHsp70Mitochondrial DNAGenetics
DOInot available

Abstract

fetched live from OpenAlex

OPA1 encoded by a nuclear gene,belongs to mitochondria shaping protein family,which is a mitochondrial inner membrane GTPase dynamic.Its variants generated by cheavaging in diffrent positions involve in mitochondrial inner membrane fusion,and play important role in mitochondrial structure.OPA1 is directly related with four respiration complexes and affects mitochondrial respiration.In apoptosis,it plays a role as anti-apoptotic factor.Recent research shows it has function in steroidogenesis and mitochondrial respiration.OPA1 has effects on a variety of diseases,for example,Dominant Optic Atrophy.OPA1 mutants not only result in Optic disease,but also involve in Auditory neuropathy,furthermore,it work as a anti-apoptotic in heat shock response and toxicity of anticancer drugs suppression.The article focus on introducing the structure of OPA1 and its function in disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.329
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes1
Has abstractyes

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