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Record W2365729577

Research Progress of OPA1

2014· article· en· W2365729577 on OpenAlexaff
Nie Wei-tia

Bibliographic record

VenueXiandai shengwu yixue jinzhan · 2014
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMitochondrial Function and Pathology
Canadian institutionsScience North
Fundersnot available
KeywordsMitochondrionApoptosisBiologymitochondrial fusionHeat shock proteinCell biologyInner mitochondrial membraneAtrophyHSP60MutantInner membraneFunction (biology)GeneHsp70Mitochondrial DNAGenetics
DOInot available

Abstract

fetched live from OpenAlex

OPA1 encoded by a nuclear gene,belongs to mitochondria shaping protein family,which is a mitochondrial inner membrane GTPase dynamic.Its variants generated by cheavaging in diffrent positions involve in mitochondrial inner membrane fusion,and play important role in mitochondrial structure.OPA1 is directly related with four respiration complexes and affects mitochondrial respiration.In apoptosis,it plays a role as anti-apoptotic factor.Recent research shows it has function in steroidogenesis and mitochondrial respiration.OPA1 has effects on a variety of diseases,for example,Dominant Optic Atrophy.OPA1 mutants not only result in Optic disease,but also involve in Auditory neuropathy,furthermore,it work as a anti-apoptotic in heat shock response and toxicity of anticancer drugs suppression.The article focus on introducing the structure of OPA1 and its function in disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.606
Threshold uncertainty score0.435

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.329
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes1
Has abstractyes

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