Induction of Radiation Adaptive Response in Lymphocytes of Patients Undergoing Thyroid Scan
Bibliographic record
Abstract
Objective The purpose of this study is to ascertain whether radiation adaptive response could be induced by Tc-99m in peripheral lymphocytes of patients undergoing Thyroid scan.The radiation adaptive response was determined by comparing the numbers of chromosomal aberrations by high dose gamma irradiation in lymphocytes obtained before and after Thyroid scan and by showing that application of the cycloheximide,a protein synthesis inhibitor,prevent the adaptive response.Methods Lymphocytes from 21 patients(8 males,13 females,mean age 45±14 years) were collected before and after Thyroid scanwhich was done after intravenous injection of 185 MBq Tc-99m Lymphocytes from 10 controls(6 males,4 females,mean age 43± 7 years) were also collected.They were exposed to challenge dose of 2Gy gamma rays using a cell irradiator(Nordion,Canada).Number of ring form(R) and dicentric(D) chromosomes per 600 cells(chromosomal aberrations,CA) was counted under the light microscope,andused to calculate the frequency of chromosomal aberration.Ydr,which was defined was the sum of R and D divided by the total number of counted lymphocytes.Results Ydr in patients before mundergoing Thyroid scan(0.06±0.04) was not different from those of controls(0.05±0.02)(t=1.5,P0.05).However,Ydr after the challenge irradiation of 2 Gy was significantly lower in patients after undergoing Thyroid scan than beforeThyroid scan(0.15±0.03 vs 0.18±0.03,t=3.5,P0.01 by ANOVA test).Cycloheximide(CHM),an inhibitor of protein synthesis,abolished this effect.Ydr after CHM(0.19 ±0.02) was significantly higher than Ydr after undergoing Thyroid scan(0.15±0.03,t=3.5,P0.001),but was not different from before undergoing Thyroid scan(0.18±0.03,t=1.5,P0.05).Conclusion Low dose gamma-irradiation by Tc-99m used for undergoing Thyroid scan induces a cytogenetic adaptive response in peripheral lymphocytes.Which is associated with protein synthesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".