Synthesis of 3-(2-Carboxyethyl)-1H-pyrrolopyridine-2-carboxylic Acid by Heck Reaction
Why this work is in the frame
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Bibliographic record
Abstract
A novel compound,ethyl 3-(2-carboxyethyl)-1H-pyrrolopyridine-2-carboxylate,was synthesized by a five-step reaction from 1H-pyrrolopyridine-2-carboxylic acid.The structure was characterized by 1H NMR and HR-MS.The optimal Heck coupling reaction conditions of synthesizing(E)-ethyl 3-(3-ethoxy-3-oxoprop-1-en-1-yl)-1-tosyl-1H-pyrrolopyridine-2-carboxylate were as follows: The solvent was anhydrous DMF,the catalyst was Pd(OAc)2,the ligand was dppf,and the base was Et3N.The yield was 88% under the optical reaction conditions.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it