Both urokinase-type plasminogen activator (uPA) and its receptor (uPAR) relate to stage and prognosis of gastric carcinoma
Bibliographic record
Abstract
Objective To evaluate the relationship between uPA, uPAR, stage and prognosis of gastric carcinoma (GC). Methods Both uPA and uPAR were measured by ELISA in plasma, tumor extracts, paratumor and metastasis tissue in GC. The plasma of hernia and thyroid adenoma patients and the gastric tissue of benign ulcer were as control group. the p53,nm23 and CEA were detected in tumor by immunohistochemistry.Results In control group, uPA and uPAR were 0.65±0.21 ng/ml and 0.71±0.22 ng/ml in plasma, and 0.71±0.33 ng/ml and 0.88±0.42 ng/ml in gastric tissue respectively. In GC group, uPA and uPAR were 1.98±0.41 ng/ml and 2.39±0.32 ng/ml in plasma, and 2.12±0.44 ng/ml and 2.68±0.40 ng/ml in tumor tissue , compared to control respectively, P 0.05. uPA and uPAR were 1.14±0.32 ng/ml and 1.30±0.41 ng/ml in paratumor tissue, and 3.63±0.77 ng/ml and 4.04±0.87 ng/ml in metastasis lesion. Pathological type of low differentiation was higher than others type, they were 2.57±0.38 ng/ml and 3.38±0.47 ng/ml vs 1.74±0.63 ng/ml and 2.06±0.43 ng/ml, P 0.05 . In stage I of GC , uPA and uPAR were close to control group in plasma, they were 0.90±0.21 ng/ml and 0.99±0.34 ng/ml , moving up trend was showed from stage II to IV of GC. They were 2.78±0.27 ng/ml and 3.12±0.31 ng/ml in the stage IV of GC, compared with stage I, P 0.05. Thirty eight cases of GC were followed up: 5 years survival rate was 73.33% in stage I and II, 52.63% in stage III, 0% in stage IV. p53、nm23 and CEA have nothing to do with GC Stage .Conclusion Both uPA and uPAR were increased progressively according to GC staging. uPA and uPAR correlated closely in GC invasiveness, metastasis, poorly pathological kinds and prognosis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".